Induction of DNA-protein crosslinks by antitumor 1-nitro-9-aminoacridines in L1210 leukemia cells

Topoisomerase II is a structural component of mitotic chromosome scaffolds.

William C. Earnshaw, Brian Halligan, Carol Cooke et al. · The Journal of Cell Biology · 1985 · 761 citations · Full text

Life Sciences, Biochemistry, Cell Biology +13

X-ray induced DNA double strand break production and repair in mammalian cells as measured by neutral filter elution

Matthews O. Bradley, Kurt W. Kohn · Nucleic Acids Research · 1979 · 572 citations · Full text

Medicine, Cancer Biology, Molecular Biology +16

Mechanism of antitumor drug action: poisoning of mammalian DNA topoisomerase II on DNA by 4'-(9-acridinylamino)-methanesulfon-m-anisidide.

Eric M. Nelson, K M Tewey, Leroy F. Liu · Proceedings of the National Academy of Sciences · 1984 · 562 citations

Medicine, Molecular Biology, Pharmacology +15

Protein-associated deoxyribonucleic acid strand breaks in L1210 cells treated with the deoxyribonucleic acid intercalating agents 4'-(9-acridinylamino)methanesulfon-m-anisidide and adriamycin

Leonard A. Zwelling, Stephen Michaels, Leonard C. Erickson et al. · Biochemistry · 1981 · 375 citations

Pharmacy, Cancer Biology, Molecular Biology +15

DNA damage by antitumor acridines mediated by mammalian DNA topoisomerase II.

Thomas C. Rowe, Grace L. Chen, Y H Hsiang et al. · PubMed · 1986 · 236 citations

Medicine, Molecular Biology, Oncology +15