Paliperidone protects prefrontal cortical neurons from damages caused by MK-801 via Akt1/GSK3β signaling pathway

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).

Chris J. Vlahos, William F. Matter, K. Y. Hui et al. · Journal of Biological Chemistry · 1994 · 3.3K citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +16

Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

Edward H. Walker, Michael E. Pacold, Olga Perišić et al. · Molecular Cell · 2000 · 1.2K citations · Full text

Life Sciences, Biochemistry, Pharmacology +14

Convergent evidence for impaired AKT1-GSK3β signaling in schizophrenia

Effat S. Emamian, Diana Hall, Morris J. Birnbaum et al. · Nature Genetics · 2004 · 920 citations

Medicine, Neurobiology, Neuroscience +14

NMDA Antagonist Neurotoxicity: Mechanism and Prevention

John W. Olney, Joann Labruyere, G. Wang et al. · Science · 1991 · 850 citations

Medicine, Neuroscience, Pharmacology +17

A Role for the PI-3 Kinase Signaling Pathway in Fear Conditioning and Synaptic Plasticity in the Amygdala

Chih-Hung Lin, Shiu-Hwa Yeh, Chia-Ho Lin et al. · Neuron · 2001 · 344 citations · Full text

Life Sciences, Neurobiology, Neuroscience +16