Concepedia

Sulfated polymannuroguluronate, a novel anti-AIDS drug candidate, inhibits HIV-1 Tat-induced angiogenesis in Kaposi's sarcoma cells

Congxiao Lu, Jing Li, Sun Yong-xu, Xin Qi, Qing-Juan Wang, Xianliang Xin, Meiyu Geng

Biochemical Pharmacology · 2007 · 22 citations · 37 references

DOI

Concepts

References

37

Tat protein of HIV-1 stimulates growth of cells derived from Kaposi's sarcoma lesions of AIDS patients

Barbara Ensoli, Giovanni Barillari, S. Zaki Salahuddin et al. · Nature · 1990 · 895 citations

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Internalization of HIV-1 Tat Requires Cell Surface Heparan Sulfate Proteoglycans

Mudit Tyagi, Marco Rusnati, Marco Presta et al. · Journal of Biological Chemistry · 2001 · 717 citations · Full text

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Synergy between basic fibroblast growth factor and HIV-1 Tat protein in induction of Kaposi's sarcoma

Barbara Ensoli, Rita Gendelman, Phillip D. Markham et al. · Nature · 1994 · 572 citations

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The angiogenesis induced by HIV–1 Tat protein is mediated by the Flk–1/KDR receptor on vascular endothelial cells

Adriana Albini, Raffaella Soldi, Daniela Giunciuclio et al. · Nature Medicine · 1996 · 376 citations

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The Tat protein of human immunodeficiency virus type 1, a growth factor for AIDS Kaposi sarcoma and cytokine-activated vascular cells, induces adhesion of the same cell types by using integrin receptors recognizing the RGD amino acid sequence.

Giovanni Barillari, R Gendelman, R C Gallo et al. · Proceedings of the National Academy of Sciences · 1993 · 356 citations · Full text

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