Release, uptake, and effects of extracellular human immunodeficiency virus type 1 Tat protein on cell growth and viral transactivation

Barbara Ensoli, Luigi Buonaguro, Giovanni Barillari, +5

Journal of Virology

The Tat protein of human immunodeficiency virus type 1, a growth factor for AIDS Kaposi sarcoma and cytokine-activated vascular cells, induces adhesion of the same cell types by using integrin receptors recognizing the RGD amino acid sequence.

Giovanni Barillari, R Gendelman, R C Gallo, +1

Proceedings of the National Academy of Sciences

Cell AdhesionImmunologyImmune RegulationPathologyImmunologic Mechanism +16

Vascular endothelial growth factor and basic fibroblast growth factor present in Kaposi's sarcoma (KS) are induced by inflammatory cytokines and synergize to promote vascular permeability and KS lesion development.

Felipe Samaniego, P. D. Markham, R Gendelman, +7

PubMed

Cytokines from activated T cells induce normal endothelial cells to acquire the phenotypic and functional features of AIDS-Kaposi's sarcoma spindle cells.

Valeria Fiorelli, R Gendelman, Felipe Samaniego, +2

Journal of Clinical Investigation

ImmunologyImmune RegulationPathologyImmunologic MechanismT Cells +17

Block of AIDS-Kaposi's sarcoma (KS) cell growth, angiogenesis, and lesion formation in nude mice by antisense oligonucleotide targeting basic fibroblast growth factor. A novel strategy for the therapy of KS.

Barbara Ensoli, P D Markham, V Kao, +6

Journal of Clinical Investigation

Bfgf MrnaImmunologyPathologyTumor BiologyCancer-associated Virus +16

Inflammatory cytokines synergize with the HIV-1 Tat protein to promote angiogenesis and Kaposi's sarcoma via induction of basic fibroblast growth factor and the alpha v beta 3 integrin.

Giovanni Barillari, Cecilia Sgadari, Clelia Palladino, +8

PubMed

ImmunologyImmune RegulationPathologyImmunologic MechanismImmunotherapy +15

Identification and culture of Kaposi's sarcoma-like spindle cells from the peripheral blood of human immunodeficiency virus-1-infected individuals and normal controls [see comments]

PJ Browning, JM Sechler, M Kaplan, +5

Blood

Inflammatory cytokines induce endothelial cells to produce and release basic fibroblast growth factor and to promote Kaposi's sarcoma-like lesions in nude mice

Felipe Samaniego, P. D. Markham, R Gendelman, +2

The Journal of Immunology

Specific Identification of Human Papillomavirus Type in Cervical Smears and Paraffin Sections by In Situ Hybridization with Radioactive Probes

Jean Gupta, R Gendelman, Zohreh Naghashfar, +5

International Journal of Gynecological Pathology

Immunihistochemical detection of Bcl-2 in AIDS-associated and classical Kaposi's sarcoma.

Cindy Morris, R Gendelman, Aizen J. Marrogi, +4

PubMed