Antithrombotic properties of a direct thrombin inhibitor with a prolonged half-life and AT-mediated factor Xa inhibitory activity

Clot-bound thrombin is protected from inhibition by heparin-antithrombin III but is susceptible to inactivation by antithrombin III-independent inhibitors.

Jeffrey I. Weitz, Monika Hudoba, David Massel et al. · Journal of Clinical Investigation · 1990 · 1.1K citations · Full text

Medicine, Cardiology, Pharmacology +16

A comparison of recombinant Hirudin with Heparin for the treatment of acute coronary syndromes. The Global Use of Strategies to Open Occluded Coronary Arteries (GUSTO) IIb Investigators

Maarten L. Simoons · RePub (Erasmus University, Rotterdam) · 1996 · 706 citations · Full text

Medicine, Cardiology, Pharmacology +14

A diagnostic test for heparin-induced thrombocytopenia

D Sheridan, C Carter, JG Kelton · Blood · 1986 · 702 citations · Full text

Medicine, Hematology, Pathology +14

A Comparison of Recombinant Hirudin with Heparin for the Treatment of Acute Coronary Syndromes

The Global Use of Strategies to Open Occluded Coronary Arteries IIb Investigators · New England Journal of Medicine · 1996 · 663 citations · Full text

Medicine, Cardiology, Pharmacology +15

Persistent activation of coagulation mechanism in unstable angina and myocardial infarction.

P A Merlini, Kenneth A. Bauer, Luigi Oltrona et al. · Circulation · 1994 · 599 citations

Medicine, Cardiology, Hematology +15