The Compensatory Anti-inflammatory Cytokine Interleukin 10 Response in Pediatric Sepsis-Induced Multiple Organ Failure

Interleukin-10-deficient mice develop chronic enterocolitis

Ralf Kühn, Jürgen Löhler, D Rennick et al. · Cell · 1993 · 4.3K citations

Veterinary Medicine, Immunology, Infectious Diseases +14

Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes.

René de Waal Malefyt, J S Abrams, B Bennett et al. · The Journal of Experimental Medicine · 1991 · 3.8K citations · Full text

Life Sciences, Immunology, Immunoregulation +10

Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression.

René de Waal Malefyt, John B.A.G. Haanen, Hergen Spits et al. · The Journal of Experimental Medicine · 1991 · 1.9K citations · Full text

Life Sciences, Cell Biology, Immunology +15

Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes.

F Rousset, Elisabeth Garcia, Thierry Defrance et al. · Proceedings of the National Academy of Sciences · 1992 · 1.3K citations

Life Sciences, Cell Biology, Immunology +17

Interleukin 10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia.

Catherine Gérard, Catherine Bruyns, Arnaud Marchant et al. · The Journal of Experimental Medicine · 1993 · 800 citations · Full text

Veterinary Medicine, Immunology, Pharmacology +17