Concepedia

Novel Multicomponent Reaction for the Combinatorial Synthesis of 2-Imidazolines

Robin S. Bon, Chongen Hong, Marinus J. Bouma, Frans J. J. de Kanter, Martin Lutz, A Spek, Romano V. A. Orrù

Organic Letters · 2003 · 110 citations · 16 references

DOI

Abstract

[reaction: see text] The three-component condensation between an amine, an aldehyde, and an alpha-acidic isocyanide efficiently provides substituted 2-imidazolines in a one-pot reaction under mild conditions.

References

16

Multicomponent Reactions with Isocyanides

Alexander Dömlingꝉ, Ivar Ugi · Angewandte Chemie International Edition · 2000 · 4K citations

Multiple-Component Condensation Strategies for Combinatorial Library Synthesis

Robert W. Armstrong, Andrew P. Combs, Paul Tempest et al. · Accounts of Chemical Research · 1996 · 1.1K citations

, , +15

Maximizing Synthetic Efficiency: Multi-Component Transformations Lead the Way

Hugues Bienaymé, Chris Hulme, G. ODDON et al. · Chemistry - A European Journal · 2000 · 1.1K citations · Full text

, , +17

The Design of Leadlike Combinatorial Libraries

Simon J. Teague, A. M. Davis, Paul D. Leeson et al. · Angewandte Chemie International Edition · 1999 · 801 citations

, , +23

Chemistry of sulfonylmethyl isocyanides. 12. Base-induced cycloaddition of sulfonylmethyl isocyanides to carbon,nitrogen double bonds. Synthesis of 1,5-disubstituted and 1,4,5-trisubstituted imidazoles from aldimines and imidoyl chlorides

A. M. VAN LEUSEN, Jurjen Wildeman, O. H. OLDENZIEL · The Journal of Organic Chemistry · 1977 · 310 citations

, , +10