Concepedia

Protecting-group-free synthesis of a dual CCK1/CCK2 receptor antagonist

Jing Liu, Xiaohu Deng, Anne E. Fitzgerald, Zachary S. Sales, Hariharan Venkatesan, Neelakandha S. Mani

Organic & Biomolecular Chemistry · 2011 · 13 citations · 44 references

DOI

Concepts

Abstract

In our pursuit of an efficient, protecting-group-free synthesis of the dual CCK1/CCK2 receptor antagonist 1, we have developed chemoselective conditions for sulfonamide formation reaction in pure water and a PhNMe(2) mediated carboxamide formation, both in the presence of a carboxylic acid. Practical synthesis of an unnatural, chiral β-aryl-α-amino acid is also described.

References

44

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