Clinical pharmacogenomics: applications in pharmaceutical R&D

Drug Discovery: A Historical Perspective

Jürgen Drews · Science · 2000 · 2.7K citations

Pharmacy, Bioinformatics, Pharmacology +7

The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans.

S.M. de Morais, G. Wilkinson, Joyce Blaisdell et al. · Journal of Biological Chemistry · 1994 · 952 citations · Full text

Medicine, Genetics, Pharmacology +17

THE INCIDENCE OF ALKAPTONURIA : A STUDY IN CHEMICAL INDIVIDUALITY.

ArchibaldE. Garrod · The Lancet · 1902 · 784 citations

Life Sciences, Chemistry, Human Genetics +3

The Role of a Common Variant of the Cholesteryl Ester Transfer Protein Gene in the Progression of Coronary Atherosclerosis

Jan Albert Kuivenhoven, J. Wouter Jukema, Aeilko H. Zwinderman et al. · New England Journal of Medicine · 1998 · 628 citations · Full text

Life Sciences, Genetics, Molecular Genetics +14

Association between genetic polymorphisms of the beta2-adrenoceptor and response to albuterol in children with and without a history of wheezing.

Fernando D. Martínez, P E Graves, Mauro Baldini et al. · Journal of Clinical Investigation · 1997 · 610 citations · Full text

Life Sciences, Genetics, Pharmacology +13