Antioxidants increase the formation of 6-oxo- PGF1α by ram seminal vesicle microsomes

An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation

Salvador Moncada, Ryszard J. Gryglewski, S Bunting et al. · Nature · 1976 · 3.6K citations

Medicine, Biochemistry, Pharmacology +16

Arterial walls are protected against deposition of platelet thrombi by a substance (prostaglandin X) which they make from prostaglandin endoperoxides

Ryszard J. Gryglewski, Stuart Bunting, Salvador Moncada et al. · Prostaglandins · 1976 · 1K citations

Medicine, Cardiology, Hematology +13

Isolation and properties of intermediates in prostaglandin biosynthesis

D.H. Nugteren, E. Hazelhof · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · 1973 · 795 citations

Life Sciences, Biochemistry, Molecular Biology +8

A lipid peroxide inhibits the enzyme in blood vessel microsomes that generates from prostaglandin endoperoxides the substance (prostaglandin X) which prevents platelet aggregation

Salvador Moncada, Ryszard J. Gryglewski, Stuart Bunting et al. · Prostaglandins · 1976 · 605 citations

Life Sciences, Biochemistry, Physiology +16

Mechanism for irreversible self-deactivation of prostaglandin synthetase.

Robert W. Egan, James W. Paxton, F. A. Kuehl · Journal of Biological Chemistry · 1976 · 589 citations · Full text

Life Sciences, Biochemistry, Enzymology +9