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Her-2/neu overexpression induces NF-κB via a PI3-kinase/Akt pathway involving calpain-mediated degradation of IκB-α that can be inhibited by the tumor suppressor PTEN

Tumor BiologySignal TransductionSignaling PathwayCell RegulationMedicineReceptor Tyrosine KinaseCalpain-mediated DegradationPi3-kinase/akt PathwayTumor SuppressorRadiation OncologyCancer BiologyCell BiologyCell SignalingCancer ResearchTumor Suppressor PtenMolecular Signaling