Alteration of behavioural phenotype in mice by targeted disruption of the progranulin gene

Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17

Matt Baker, Ian R. Mackenzie, Stuart Pickering‐Brown et al. · Nature · 2006 · 2.1K citations

Life Sciences, Genetics, Neurology +12

Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice

Philippe Soriano, Charles A. Montgomery, Robert S. Geske et al. · Cell · 1991 · 2K citations

Medicine, Molecular Biology, Oncology +12

Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21

Marc Cruts, Ilse Gijselinck, Julie van der Zee et al. · Nature · 2006 · 1.5K citations

Life Sciences, Genetics, Molecular Genetics +11

HPRT-deficient (Lesch–Nyhan) mouse embryos derived from germline colonization by cultured cells

Martin Hooper, Kate Hardy, Alan H. Handyside et al. · Nature · 1987 · 1.2K citations

Life Sciences, Developmental Biology, Genetics +16

Aggressive Behavior and Altered Amounts of Brain Serotonin and Norepinephrine in Mice Lacking MAOA

Olivier Cases, Isabelle Seif, Joseph Grimsby et al. · Science · 1995 · 1.2K citations · Full text

Life Sciences, Neurobiology, Neuroscience +16