Concepedia

Pyruvate kinase M2 promotes the growth of gastric cancer cells via regulation of Bcl-xL expression at transcriptional level

Oh‐Hyung Kwon, Tae-Wook Kang, Jeonghwan Kim, Mirang Kim, Seung‐Moo Noh, Kyu‐Sang Song, Hyang‐Sook Yoo, Woo Ho Kim, Zhi Xie, David Pocalyko,

Biochemical and Biophysical Research Communications · 2012 · 75 citations · 19 references

DOI

Concepts

References

19

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

Heather R. Christofk, Matthew G. Vander Heiden, Marian H. Harris et al. · Nature · 2008 · 2.8K citations

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Hypoxia-inducible Factor 1 Activation by Aerobic Glycolysis Implicates the Warburg Effect in Carcinogenesis

Huasheng Lu, Robert A. Forbes, Ajay Verma · Journal of Biological Chemistry · 2002 · 837 citations · Full text

, , +17

Lactate Influx through the Endothelial Cell Monocarboxylate Transporter MCT1 Supports an NF-κB/IL-8 Pathway that Drives Tumor Angiogenesis

Frédérique Végran, Romain Boidot, Carine Michiels et al. · Cancer Research · 2011 · 793 citations

, , +17

PDLIM2-mediated termination of transcription factor NF-κB activation by intranuclear sequestration and degradation of the p65 subunit

Takashi Tanaka, Michael J. Grusby, Tsuneyasu Kaisho · Nature Immunology · 2007 · 335 citations

, , +10

Pyruvate kinase M2 is a target of the tumor-suppressive microRNA-326 and regulates the survival of glioma cells

B. A. Kefas, Louis Comeau, N. Erdle et al. · Neuro-Oncology · 2010 · 237 citations · Full text

, , +17