Prostaglandin D2 induces apoptosis of human osteoclasts through ERK1/2 and Akt signaling pathways

Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2

Xiao-ding Peng, Pei-Zhang Xu, Mei-Ling Chen et al. · Genes & Development · 2003 · 826 citations · Full text

Medicine, Developmental Biology, Genetics +17

β-Arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors

Mounia Azzi, Pascale G. Charest, Stéphane Angers et al. · Proceedings of the National Academy of Sciences · 2003 · 511 citations · Full text

Life Sciences, Molecular Biology, Pharmacology +17

Interleukin-6 and interleukin-11 support human osteoclast formation by a RANKL-independent mechanism

O Kudo, A Sabokbar, A. Pocock et al. · Bone · 2003 · 468 citations

Medicine, Cell Biology, Immunology +14

Reciprocal Role of ERK and Nf-κb Pathways in Survival and Activation of Osteoclasts

Tsuyoshi Miyazaki, Hideki Katagiri, Yumi Kanegae et al. · The Journal of Cell Biology · 2000 · 382 citations · Full text

Life Sciences, Cell Biology, Oral Biology +16

Estrogen protects bone by inducing Fas ligand in osteoblasts to regulate osteoclast survival

Susan A. Krum, Gustavo A. Miranda‐Carboni, Peter V. Hauschka et al. · The EMBO Journal · 2008 · 351 citations · Full text

Medicine, Endocrinology, Orthopaedic Surgery +15