Concepedia

Poly(ADP-ribose) polymerase inhibition improves endothelial dysfunction induced by reactive oxidant hydrogen peroxide in vitro

Tamás Radovits, Li-ni Lin, Julia Zotkina, Domokos Gerő, Csaba Szabó, Matthias Karck, Gábor Szabó

European Journal of Pharmacology · 2007 · 44 citations · 32 references

DOI

Concepts

References

32

DNA strand breakage, activation of poly (ADP-ribose) synthetase, and cellular energy depletion are involved in the cytotoxicity of macrophages and smooth muscle cells exposed to peroxynitrite.

Csaba Szabó, Basilia Zingarelli, Michael O′Connor et al. · Proceedings of the National Academy of Sciences · 1996 · 624 citations · Full text

, , +17

Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation

Francisco García Soriano, László Virág, Prakash G. Jagtap et al. · Nature Medicine · 2001 · 603 citations · Full text

, , +14

Oxidant injury of cells. DNA strand-breaks activate polyadenosine diphosphate-ribose polymerase and lead to depletion of nicotinamide adenine dinucleotide.

Ingrid U. Schraufstätter, Daniel B. Hinshaw, Paul A. Hyslop et al. · Journal of Clinical Investigation · 1986 · 513 citations · Full text

, , +17

Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death

Sean P. Cregan, Andre Fortin, Jason G. MacLaurin et al. · The Journal of Cell Biology · 2002 · 479 citations · Full text

, , +17

Endothelial dysfunction in a rat model of endotoxic shock. Importance of the activation of poly (ADP-ribose) synthetase by peroxynitrite.

Csaba Szabó, Salvatore Cuzzocrea, Basilia Zingarelli et al. · Journal of Clinical Investigation · 1997 · 358 citations · Full text

, , +15