Early embryonic lethality in mice deficient in the p110β catalytic subunit of PI 3-kinase

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).

Chris J. Vlahos, William F. Matter, K. Y. Hui et al. · Journal of Biological Chemistry · 1994 · 3.3K citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +16

Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses

Alexandre Arcaro, Matthias P. Wymann · Biochemical Journal · 1993 · 1.1K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +14

Fibroblast Growth Factor Receptor 3 Is a Negative Regulator of Bone Growth

Anthony Wynshaw‐Boris, Fen Zhou, Ann Kuo et al. · Cell · 1996 · 1.1K citations · Full text

Medicine, Cell Biology, Orthopaedic Surgery +12

Impaired B Cell Development and Proliferation in Absence of Phosphoinositide 3-Kinase p85α

Scott B. Snapper, Claudine M. Yballe, Laurie A. Davidson et al. · Science · 1999 · 631 citations

Life Sciences, Genetics, Immunology +17

Phosphatidylinositol-3-OH kinases are Rab5 effectors

Savvas Christoforidis, Marta Miączyńska, Keith Ashman et al. · Nature Cell Biology · 1999 · 627 citations

Life Sciences, Biochemistry, Molecular Biology +10