RUNX1 transformation of primary embryonic fibroblasts is revealed in the absence of p53

Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a

Manuel Serrano, Athena W. Lin, Mila E. McCurrach et al. · Cell · 1997 · 5.1K citations · Full text

Medicine, Cell Biology, Oncology +10

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

Lawrence A. Donehower, Michele Harvey, Betty L. Slagle et al. · Nature · 1992 · 4.7K citations

Medicine, Cancer Biology, Molecular Genetics +14

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

Jay P. Morgenstern, Hartmut Land · Nucleic Acids Research · 1990 · 2.1K citations · Full text

Pharmacy, Pharmaceutics, Gene Delivery +15

Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia

Woo‐Joo Song, Melanie G. Sullivan, Robert D. Legare et al. · Nature Genetics · 1999 · 1.1K citations

Life Sciences, Genetics, Molecular Genetics +8

Causal Relationship between the Loss of RUNX3 Expression and Gastric Cancer

Qing-Lin Li, Kosei Ito, Chohei Sakakura et al. · Cell · 2002 · 1K citations · Full text

Medicine, Cancer Biology, Oncology +14