Characterization of YM-90709 as a novel antagonist which inhibits the binding of interleukin-5 to interleukin-5 receptor

Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model.

Paul S. Foster, Simon P. Hogan, Alistair J. Ramsay et al. · The Journal of Experimental Medicine · 1996 · 1.4K citations · Full text

Inflammation, Asthma, Allergy +15

Mast cell lines produce lymphokines in response to cross-linkage of FcεRI or to calcium ionophores

Marshall Plaut, Jacalyn H. Pierce, Cynthia J. Watson et al. · Nature · 1989 · 1.2K citations

Signal Transduction, Mast Cell Lines, Mast Cell Disorder +10

Recombinant human interleukin 5 is a selective activator of human eosinophil function.

Angel F. López, Colin J. Sanderson, Jennifer R. Gamble et al. · The Journal of Experimental Medicine · 1988 · 958 citations · Full text

Selective Eosinophilia, Immune Regulation, Immunology +17

Human interleukin-5 (IL-5) regulates the production of eosinophils in human bone marrow cultures: comparison and interaction with IL-1, IL-3, IL-6, and GMCSF

EJ Clutterbuck, EM Hirst, CJ Sanderson · Blood · 1989 · 675 citations

Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF): reconstitution of a high-affinity GM-CSF receptor.

Kazuhiro Hayashida, Toshio Kitamura, D M Gorman et al. · Proceedings of the National Academy of Sciences · 1990 · 640 citations · Full text

Immune Regulation, Immunology, Low-affinity Gm-csf Receptor +16