Hypermutation generating the sheep immunoglobulin repertoire is an antigen-independent process

Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice

Christopher C. Goodnow, J. Crosbie, Stephen Adelstein et al. · Nature · 1988 · 1.6K citations

Autoimmune Disease, Lymphocyte Development, Immunology +9

Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes

David Nemazee, Kurt Bürki · Nature · 1989 · 1K citations

Histocompatibility, Anti-mhc Class, Immunogenetics +9

Genes and Antibodies

Joshua Lederberg · Science · 1959 · 676 citations

Immunogenetics, Autoimmune Disease, Genetics +7

Junctional sequences of T cell receptor γδ genes: Implications for γδ T cell lineages and for a novel intermediate of V-(D)-J joining

Juan J. Lafaille, Amy DeCloux, Marc Bonneville et al. · Cell · 1989 · 564 citations

Junctional Sequences, Lymphocyte Development, Immunology +5

Somatic hypermutagenesis in immunoglobulin genes

Igor B. Rogozin · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · 1992 · 459 citations

Somatic Variant, Autoimmune Disease, Medicine +6