The barrier function of CYP3A4 and P-glycoprotein in the small bowel

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.

F Thiébaut, T Tsuruo, Hironobu Hamada et al. · Proceedings of the National Academy of Sciences · 1987 · 2.8K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +9

Human P-glycoprotein transports cyclosporin A and FK506.

Takashi Saeki, Kazumitsu Ueda, Yusuke Tanigawara et al. · Journal of Biological Chemistry · 1993 · 685 citations · Full text

Medicine, Biochemistry, Pharmacology +15

Grapefruit juice increases felodipine oral availability in humans by decreasing intestinal CYP3A protein expression.

Kenneth S. Lown, David G. Bailey, Robert J. Fontana et al. · Journal of Clinical Investigation · 1997 · 628 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +11

Cyclosporine metabolism in human liver: Identification of a cytochrome P-450III gene family as the major cyclosporine-metabolizing enzyme explains interactions of cyclosporine with other drugs

Thomas Kronbach, Volker Fischer, Urs Meyer · Clinical Pharmacology & Therapeutics · 1988 · 539 citations

Medicine, Biochemistry, Pharmacology +17

Identification of rifampin-inducible P450IIIA4 (CYP3A4) in human small bowel enterocytes.

Joseph C. Kolars, Phyllissa Schmiedlin‐Ren, John D. Schuetz et al. · Journal of Clinical Investigation · 1992 · 533 citations · Full text

Medicine, Molecular Biology, Pharmacology +14