Science · 1979 · 146 citations · 16 references
MedicineCancer BiologyOncologyBone MetabolismMetastasisTumor MicroenvironmentBone MetastasisBone ResorptionBone TumorsMetastatic Bone DiseaseMetastatic DisseminationTumor InvasionBone Tumor MetastasisCancer Cell MigrationChemotactic Cell RecruitmentChemotactic MediatorsChemotactic SignalingTumor Cell Homing To BoneTumor-associated Bone ResorptionTumor-bone Microenvironment
To explore possible mechanisms for the metastasis of malignant cells to bone, a model of tumor cell migration was developed, using Walker carcinosarcoma or malignant lymphoma cells. It was found that bone contains a factor that is strongly chemotactic for tumor cells. This factoor is released by a variety of agents that induce resorption of bone.
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