Helvetica Chimica Acta · 1987 · 91 citations · 1 references
Life SciencesMedicinal ChemistryPharmacologyBiochemical PharmacologyEnzymologySynthetic Medicinal ChemistryEnzyme InhibitionLipid ChemistryLipid DigestionLipid MetabolismTriglyceride MetabolismAbsolute Configuration AssignmentAbsolute Configuration DeterminationLipase InhibitionLipase InhibitorsLipasesNatural Product PharmacologyNatural Product SynthesisPancreatic Lipase Action
Abstract Lipstatin ( 1 ), a natural product, and tetrahydrolipstatin ( 2 ) are pancreatic lipase inhibitors. Non‐stereoselective and partially stereoselective syntheses of 2 are used to establish the absolute configuration of tetrahydrolipstatin and lipstatin.
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