Combination of the anti-tumour cell ether lipid edelfosine with sterols abolishes haemolytic side effects of the drug

Spontaneous Curvature of Phosphatidic Acid and Lysophosphatidic Acid

Edgar E. Kooijman, Vladimir Chupin, N. L. Fuller et al. · Biochemistry · 2005 · 297 citations · Full text

Natural Sciences, Biochemistry, Biophysics +17

Edelfosine and perifosine induce selective apoptosis in multiple myeloma by recruitment of death receptors and downstream signaling molecules into lipid rafts

Consuelo Gajate, Faustino Mollinedo · Blood · 2006 · 277 citations · Full text

Life Sciences, Cell Biology, Oncology +17

The antitumor ether lipid ET-18-OCH3 induces apoptosis through translocation and capping of Fas/CD95 into membrane rafts in human leukemic cells

Consuelo Gajate, Faustino Mollinedo · Blood · 2001 · 272 citations

Life Sciences, Cell Biology, Oncology +15

Selective induction of apoptosis in cancer cells by the ether lipid ET-18-OCH3 (Edelfosine): molecular structure requirements, cellular uptake, and protection by Bcl-2 and Bcl-X(L).

Faustino Mollinedo, José L. Fernández-Luna, Consuelo Gajate et al. · PubMed · 1997 · 223 citations

Life Sciences, Oncology, Pharmacology +15

Intracellular Triggering of Fas Aggregation and Recruitment of Apoptotic Molecules into Fas-enriched Rafts in Selective Tumor Cell Apoptosis

Consuelo Gajate, Esther del Canto-Jañez, A. Ulises Acuña et al. · The Journal of Experimental Medicine · 2004 · 214 citations · Full text

Life Sciences, Cell Biology, Oncology +17