Concepedia

Alginate Microencapsulated Hepatocytes Optimised for Transplantation in Acute Liver Failure

Suttiruk Jitraruch, Anil Dhawan, Robin D. Hughes, Céline Filippi, Daniel Soong, Christina Philippeos, Sharon C. Lehec, Nigel Heaton, Maria Serena Longhi, Ragai R. Mitry

PLoS ONE · 2014 · 124 citations · 26 references

DOIFull text

Open access

Abstract

An optimised protocol to produce GMP grade alginate-encapsulated human hepatocytes has been established. Transplantation of microbeads provided effective metabolic function in ALF. These high quality HMBs should be suitable for use in clinical transplantation.

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