Advanced Oxidation Protein Products Activate Intrarenal Renin–Angiotensin System <i>via</i> a CD36-Mediated, Redox-Dependent Pathway

Abstract

This study demonstrated for the first time that AOPPs modified albumin functions as a strong trigger of intrarenal RAS via a CD36-mediated, redox-dependent pathway. Given the fact that accumulation of AOPPs is prevalent in diabetes and CKD, targeting AOPPs could be a strategy for the therapeutic intervention of CKD. Antioxid. Redox Signal. 18, 19-35.