Future Oncology · 2014 · 43 citations · 48 references
MedicineMolecular MedicineOncologyGastrointestinal OncologyMolecular DiagnosticsMolecular OncologyCancer BiomarkersCancer Molecular DiagnosticsCancer Survival AnalysisGastric CancerMolecular Tumor ProfilingTumor MarkersBiomarkers Of Gastric CancerCirculating MicrornasCirculating Tumor BiomarkersDiagnostic BiomarkersMicrorna In CancerMicrorna Prognostic MarkersMolecular Prognostic MarkersUnivariate Analysis
AIM: To analyze GDF15 and MMP7 serum levels as diagnostic biomarkers in gastric cancer (GC) patients. The prognostic value of GDF15 and MMP7 serum levels in combination with miR-200c blood expression was also analyzed. PATIENTS & METHODS: Fifty-two GC and 23 control samples were included. RESULTS: GDF15 and MMP7 proved to be powerful tools for GC diagnosis. Increased levels of GDF15 and MMP7 were associated with shorter progression-free survival and overall survival in univariate analysis. In multivariate analysis, the combination of high levels of GDF15, MMP7 and miR-200c was an independent predictor for death (p = 0.033). CONCLUSION: GDF15 and MMP7 serum levels have diagnostic value for GC. The combination marker formed by GDF15, MMP7 and miR-200c is indicative of adverse evolution in GC patients.
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Prediction of Mammalian MicroRNA Targets
Benjamin P. Lewis, I‐hung Shih, Matthew W. Jones-Rhoades et al. · Cell · 2003 · 5.2K citations · Full text
Robert L. Camp, Marisa Dolled‐Filhart, David L. Rimm · Clinical Cancer Research · 2004 · 3.9K citations
Medicine, Biostatistics, Oncology +17