Antidiabetic effect and antioxidant potential of Rosa canina fruits

Abstract

Rosa canina L. fruits (Rosaceae) are used to treat diabetes in Anatolia traditionally [1,2,3]. In this study, the ethanol extract of R. canina fruits and its fractions were screened for their antioxidant, hypoglycaemic and antidiabetic activities. Two doses of ethanol extract (250 and 500mg/kg) was administered to streptozotocin (STZ) induced diabetic rats for 7 days. The extract possessed a remarkable hypoglycemic effect at 250mg/kg dose. Then it was fractionated through successive solvent extractions to yield chloroform fraction (CHCl3 Fr.), ethyl acetate fraction (EtOAc Fr.), n-butyl alcohol fraction (n-BuOH Fr.) and remaining water fraction (R-H2O Fr.) respectively. These fractions were administered to normal plus glucose hyperglycaemic rats. Additionally the subacute antidiabetic activities of the fractions were studied in diabetic rats for 7 days (10, 40, 150 and 300mg/kg dose respectively).