Asymmetric Synthesis of Ring Functionalized<i>trans</i>-2,6-Disubstituted Piperidines from<i>N</i>-Sulfinyl δ-Amino β-Keto Phosphonates. Total Synthesis of (−)-Myrtine

Abstract

Sulfinimine-derived N-sulfinyl delta-amino beta-ketophosphonates are transformed via the enaminones to the phosphoryl dihydropyridones that selectively give trans-2,6-disubstituted 1,2,5,6-tetrahydropyridines on organocuprate addition and dephosphorylation.