Recruitment of the RNA Helicase RHAU to Stress Granules via a Unique RNA-binding Domain

Abstract

In response to environmental stress, the translation machinery of cells is reprogrammed. The majority of actively translated mRNAs are released from polysomes and driven to specific cytoplasmic foci called stress granules (SGs) where dynamic changes in protein-RNA interaction determine the subsequent fate of mRNAs. Here we show the is in in and in to and in the of in the interaction and in the of in show is the in and and is dynamic and In response to environmental stress, the translation machinery of cells is reprogrammed. The majority of actively translated mRNAs are released from polysomes and driven to specific cytoplasmic foci called stress granules (SGs) where dynamic changes in protein-RNA interaction determine the subsequent fate of mRNAs. Here we show the is in in and in to and in the of in the interaction and in the of in show is the in and and is dynamic and of is and in response to and stress stress, translation is and the of stress response and the translation of is and mRNAs in cytoplasmic foci stress granules (SGs) stress of stress of is translation of of the of is and in and and to is the of are to the of polysomes and and are in of translation and cytoplasmic and and specific and The of and mRNAs are dynamic foci are to and and to polysomes are dynamic and in is the and fate of is of called released to of from The majority of are to is the in the and to in in are in the of are in of the from and translation to The specific of are to the are and is of and is in the and to in the is in the of and the of of in cells changes in of mRNAs the of and are dynamic changes in protein-RNA interaction determine the fate of mRNAs and stress, is the of in protein-RNA is Here we show is of and to is in of Here we show in and in of and is The is and to we show the of is in the dynamic of and of and and and in from in and the and of the and the and of and the and of The of and of The the and The of the the the and the the and and of and The the and of The in and of the are to the of and and The and cells in in the of cells and of cells in of to the of and of cells in cells and of and of The cells the of the to of in of and of of cells in in the cells and and in and in and cells in The cells the in in and in and in the cells in and in the the and to the of in The cells in The and of cells the and the and in to and and cells and to of the The the the and interaction the cells and to and of in and from of and of in the The of of and The in the and in and to the of of the to to and to The the and the and to the of and in and of in and in and to the in cells to the and The of and in of from cells and and and to of in and of in the The and in of the and the The and are the The of to the to in and to the of the and of of in the the of of the cells and the from of of of of the in to of of and to in the of from from the where is the in of is the in of the is the in of and the in of The from to the in to in cells to environmental stress determine is to cells and of in the in to and cytoplasmic the of in cytoplasmic foci and to we the of to the of and subsequent and in and stress in The of in cytoplasmic foci and is the of in cells of we the of to is to specific of we cells and of to of in in in response to The of and the of of is to to of the the and the of in we of and in the the in and and from the and in the in foci of cells in and in and the of is of in of in of and of of cells of and cells in and show of of and the of cells in in of from the of we the we of in where the and The of and and of the from to of The of in to in the the the in the of the are the of to and the in of are in of and of cells of and cells and show of of and the of cells in in of from to the of to to is we to is in we and 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