Screening of Inhibitors of HIV-1 Protease Using anEscherichia coliCell Assay

Active human immunodeficiency virus protease is required for viral infectivity.

Nancy E. Kohl, Emilio A. Emini, William A. Schleif et al. · Proceedings of the National Academy of Sciences · 1988 · 1.3K citations · Full text

Protease Inhibitors, Viral Replication, Molecular Virology +14

A structural model for the retroviral proteases

Laurence H. Pearl, William R. Taylor · Nature · 1987 · 591 citations

Virus Structure, Viral Replication, Protein Folding +5

Sensitive, soluble chromogenic substrates for HIV-1 proteinase.

Anthony D. Richards, Lowri H. Phylip, William G. Farmerie et al. · Journal of Biological Chemistry · 1990 · 199 citations · Full text

Protein Chemistry, Kappa Cat, Viral Replication +14

Dissociative inhibition of dimeric enzymes. Kinetic characterization of the inhibition of HIV-1 protease by its COOH-terminal tetrapeptide

Z.Y. Zhang, Roger A. Poorman, Linda Maggiora et al. · Journal of Biological Chemistry · 1991 · 149 citations · Full text

Protein Assembly, Dissociation Constant, Molecular Biology +17

Defining the level of human immunodeficiency virus type 1 (HIV-1) protease activity required for HIV-1 particle maturation and infectivity

Jacqueline Rose, Lilia M. Babé, Charles S. Craik · Journal of Virology · 1995 · 126 citations · Full text

Viral Replication, Virion Maturation, Immunology +19