Disruption of Sag/Rbx2/Roc2 induces radiosensitization by increasing ROS levels and blocking NF-κB activation in mouse embryonic stem cells

The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB

Vito J. Palombella, Oliver J. Rando, Alfred L. Goldberg et al. · Cell · 1994 · 2.1K citations

Transcriptional Regulation, Protein Function, Signal Transduction +14

SKP1 Connects Cell Cycle Regulators to the Ubiquitin Proteolysis Machinery through a Novel Motif, the F-Box

Chang Bai, Partha Sen, Kay Hofmann et al. · Cell · 1996 · 1.4K citations · Full text

Protein Function, Cell Regulation, Cell Division +11

F-Box Proteins Are Receptors that Recruit Phosphorylated Substrates to the SCF Ubiquitin-Ligase Complex

Dorota Skowyra, Karen Craig, Mike Tyers et al. · Cell · 1997 · 1.2K citations · Full text

Scf Ubiquitin-ligase Complex, Protein Function, Signal Transduction +10

VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases

Takumi Kamura, Katsumi Maenaka, Shuhei Kotoshiba et al. · Genes & Development · 2004 · 479 citations · Full text

ROC1, a Homolog of APC11, Represents a Family of Cullin Partners with an Associated Ubiquitin Ligase Activity

Tomohiko Ohta, Jennifer J. Carlisle Michel, Arndt Schottelius et al. · Molecular Cell · 1999 · 460 citations · Full text

Cullin Partners, Protein Function, Medicine +7