Anti-inflammatory activity of a water extract of Acorus calamus L. leaves on keratinocyte HaCaT cells

Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3

Lena Alexopoulou, Agnieszka Czopik Holt, Ruslan Medzhitov et al. · Nature · 2001 · 6K citations

Inflammation, Toll-like Receptors, Molecular Immunology +14

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

Mitsutoshi Yoneyama, Mika Kikuchi, Takashi Natsukawa et al. · Nature Immunology · 2004 · 3.8K citations

Essential Function, Viral Replication, Molecular Virology +10

Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling

Ruey‐Bing Yang, Melanie R. Mark, Alane Gray et al. · Nature · 1998 · 1.2K citations

Inflammation, Toll-like Receptors, Signal Transduction +6

Site-Specific Phosphorylation of IκBα by a Novel Ubiquitination-Dependent Protein Kinase Activity

Zhijian J. Chen, Lana Parent, Tom Maniatis · Cell · 1996 · 955 citations · Full text

Signal Transduction, Signaling Pathway, Molecular Regulation +11

Virus-Dependent Phosphorylation of the IRF-3 Transcription Factor Regulates Nuclear Translocation, Transactivation Potential, and Proteasome-Mediated Degradation

Rongtuan Lin, Christophe Heylbroeck, Paula M. Pitha et al. · Molecular and Cellular Biology · 1998 · 913 citations · Full text