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L-741,494, a Fungal Metabolite That Is an Inhibitor of Interleukin-1β Converting Enzyme
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1994
Year
Interleukin-1β Converting EnzymeBiosynthesisGamma-pyrone-3-acetic AcidBiochemistryFungal Cell BiologyMedicineImmunologyMedicinal FungiFungal Genus XylariaSecondary MetaboliteNatural Product BiosynthesisFungal PhysiologyMicrobiologyMetabolomicsName Xylaric AcidPharmacologyFungal Metabolite ThatDrug Discovery
gamma-Pyrone-3-acetic acid (L-741,494) is a novel metabolite produced by a culture of the fungal genus Xylaria. This substance is a water-soluble, competitive, irreversible inhibitor of Interleukin-1 beta Converting Enzyme that is inactive against papain and trypsin. It has a mol wt of 154 and an empirical formula of C7H6O4. We propose the name xylaric acid for this compound.