Angewandte Chemie International Edition · 2012 · 42 citations · 32 references
Life SciencesBiochemistryBiophysicsBiophysical ChemistryMolecular BiophysicsProtein BiochemistryConformational AnalysisConformational DynamicsProtein ConformationProtein DynamicsProtein ElectrophoresisProtein StructureCapillary ElectrophoresisConformational Dynamics AnalysisConformational Transition KineticsKinetic Models Of Conformational ChangeProtein Conformation AnalysisProtein Conformational ChangesProtein Conformational DynamicsProtein-ligand Binding Thermodynamics
Conformational analysis: Capillary electrophoresis (CE) allows for the rapid separation of slowly interconverting protein conformers. Kinetic analysis (k(open), k(closed), and K(d)) of electropherograms in the presence and absence of effector ligands allows the measurement of kinetic and thermodynamic constants associated with conformational changes and ligand binding.
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