Enhanced detection of the pathogenic prion protein by its supramolecular association with para-sulfonato-calix[n]arene derivatives

Abstract

The supramolecular interaction between the pathogenic form of the prion protein and derivatives of the para-sulfonato-calix[n]arenes has been demonstrated and two putative binding sites determined; this interaction leads to an amplification of the Western Blot immunological detection of the prion protein by the SAF84 antibody.