Interference with Feedback Control of Enzyme Activity

Abstract

The experiments described in this article have been addressed to the following questions: is the ability of an endproduct to repress enzyme synthesis linked to its ability to inhibit enzyme action, or are these effects independent of each other? Are one or the other or both of these processes responsible for the fine balance bacteria achieve between the synthesis and utilization of low molecular weight metabolites? What consequences would be entailed by the loss of such mechanisms? And, finally, can structural analogues mimic the normal inhibitory effects of their corresponding metabolites: if so, could such mimicry cause inhibition of cell growth?