Concepedia

Feedback Inhibition

Feedback Inhibition is a regulatory mechanism in metabolic pathways wherein the end product of a biosynthetic sequence acts as an allosteric inhibitor of an upstream enzyme, thereby preventing overaccumulation of the product through negative feedback.

1.4K

Publications

102.4K

Citations

5.4K

Authors

1.3K

Institutions

Publications per year

2017–2026

162

Variants

End-product Inhibition

Parents

Publications

1.4K

mTOR Inhibition Induces Upstream Receptor Tyrosine Kinase Signaling and Activates Akt

Kathryn O’Reilly, F. Rojo, Qing‐Bai She et al. · Cancer Research · 2006 · 2.6K citations · Full text

, , +16

THE SHIKIMATE PATHWAY

Klaus M. Herrmann, Lisa M. Weaver · Annual Review of Plant Physiology and Plant Molecular Biology · 1999 · 1.3K citations

, , +16

Translational control of gene expression

Ernest M. Hannig · BioEssays · 2001 · 1.2K citations

, , +17

Feedback Inhibition of Macrophage Tumor Necrosis Factor-α Production by Tristetraprolin

Ester Carballo, Wi S. Lai, Perry J. Blackshear · Science · 1998 · 1.2K citations

, , +17

Effect of Neonatal Handling on Age-Related Impairments Associated with the Hippocampus

Michael J. Meaney, David H. Aitken, Chayann van Berkel et al. · Science · 1988 · 1.1K citations

, , +17

1–5 of 1.4K

Authors

5.4K

  1. RA
    Roy A. Jensen

    University of Florida, United States

    16 publications · 907 citations

    15

    h-index

  2. NR
    Neal Rosen

    Memorial Sloan Kettering Cancer Center, United States

    12 publications · 6.6K citations

    12

    h-index

  3. SK
    Saburo Komatsubara

    Tanabe Research Laboratories, United States

    10 publications · 235 citations

    10

    h-index

  4. IS
    Isamu Shiio

    Ajinomoto (United States), United States

    10 publications · 152 citations

    10

    h-index

  5. IC
    Ichiro Chibata

    Institute of Applied Biochemistry, Japan

    8 publications · 170 citations

    8

    h-index

1–5 of 5.4K

Institutions

1.3K

  1. Harvard University

    Cambridge, United States

    32 h-index

    101 publications

    11.2K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    23 h-index

    59 publications

    11.4K citations

  3. National Institutes of Health

    Bethesda, United States

    20 h-index

    55 publications

    3.7K citations

  4. University of Washington

    Seattle, United States

    18 h-index

    48 publications

    3.5K citations

  5. University of California, San Francisco

    San Francisco, United States

    17 h-index

    71 publications

    9.2K citations

  6. Cornell University

    Ithaca, United States

    17 h-index

    58 publications

    9.1K citations

  7. University of Michigan

    Ann Arbor, United States

    16 h-index

    44 publications

    9.9K citations

  8. Memorial Sloan Kettering Cancer Center

    New York, United States

    15 h-index

    147 publications

    51.6K citations

1–8 of 1.3K

Venues

  1. Journal of Biological Chemistry

    JBC · 101 publications · 9.7K citations

    50

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 45 publications · 4.8K citations

    40

    h-index

  3. Journal of Bacteriology

    JB · 76 publications · 3.6K citations

    34

    h-index

  4. Journal of Neuroscience

    35 publications · 4.1K citations

    31

    h-index

  5. Endocrinology

    32 publications · 2.3K citations

    26

    h-index

1–5