Evidence for Increased de Novo Synthesis of NAD in Immune-Activated RAW264.7 Macrophages: A Self-Protective Mechanism?

Identification of interferon-gamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity.

Carl Nathan, Henry W. Murray, Michael E. Wiebe et al. · The Journal of Experimental Medicine · 1983 · 1.9K citations · Full text

Ifn Gamma, Innate Immune System, Immunology +17

QUINOLINIC ACID AND KYNURENINE PATHWAY METABOLISM IN INFLAMMATORY AND NON-INFLAMMATORY NEUROLOGICAL DISEASE

Melvyn P. Heyes, Kuniaki Saito, Jeffrey S. Crowley et al. · Brain · 1992 · 674 citations

DNA strand breakage, activation of poly (ADP-ribose) synthetase, and cellular energy depletion are involved in the cytotoxicity of macrophages and smooth muscle cells exposed to peroxynitrite.

Csaba Szabó, Basilia Zingarelli, Michael O′Connor et al. · Proceedings of the National Academy of Sciences · 1996 · 623 citations · Full text

Dna Damage, Lipid Peroxidation, Apoptosis +19

Oxidant injury of cells. DNA strand-breaks activate polyadenosine diphosphate-ribose polymerase and lead to depletion of nicotinamide adenine dinucleotide.

Ingrid U. Schraufstätter, Daniel B. Hinshaw, Paul A. Hyslop et al. · Journal of Clinical Investigation · 1986 · 513 citations · Full text

Dna Damage, Lipid Peroxidation, Molecular Biology +24

An improved cycling assay for nicotinamide adenine dinucleotide

Carl Bernofsky, Marcella Swan · Analytical Biochemistry · 1973 · 384 citations

Nucleic Acid Chemistry, Biochemistry, Nicotine +3