A novel mutation (G217D) in the Presenilin 1 gene (PSEN1) in a Japanese family: presenile dementia and parkinsonism are associated with cotton wool plaques in the cortex and striatum

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Amyloid precursor protein processing and Aβ ₄₂ deposition in a transgenic mouse model of Alzheimer disease

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Monoclonal antibody AT8 recognises tau protein phosphorylated at both serine 202 and threonine 205

Michel Goedert, Ross Jakes, Eugeen Vanmechelen · Neuroscience Letters · 1995 · 610 citations

Life Sciences, Biochemistry, Molecular Biology +10

The Structural Basis of Monoclonal Antibody Alz50's Selectivity for Alzheimer's Disease Pathology

Gilles Carmel, Edward M. Mager, Lester I. Binder et al. · Journal of Biological Chemistry · 1996 · 400 citations · Full text

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A variant of Alzheimer's disease with spastic paraparesis and unusual plaques due to deletion of exon 9 of presenilin 1

Richard Crook, Auli Verkkoniemi, Jordi Pérez‐Tur et al. · Nature Medicine · 1998 · 349 citations

Medicine, Genetics, Neurology +14