Toward Fully Synthetic Homogeneous Glycoproteins: A High Mannose Core Containing Glycopeptide Carrying Full H-Type 2 Human Blood Group Specificity

Abstract

Blood typing with the ABO classification is based on cell-surface glycoproteins. In a significant step toward the synthesis of these compounds, the laboratory synthesis of a fully functional N-linked glycopeptide featuring H-type blood group determinants 1 is described.