Ulrich Iserloh

Discovery of the 3-Imino-1,2,4-thiadiazinane 1,1-Dioxide Derivative Verubecestat (MK-8931)–A β-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor for the Treatment of Alzheimer’s Disease

Jack D. Scott, Sarah W. Li, Andrew P. J. Brunskill et al. · Journal of Medicinal Chemistry · 2016 · 161 citations · Full text

Neurochemical Biomarkers, Peptide Science, Enzyme 1 +19

Structure based design of iminohydantoin BACE1 inhibitors: Identification of an orally available, centrally active BACE1 inhibitor

Jared N. Cumming, Elizabeth M. Smith, Lingyan Wang et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 151 citations · Full text

Medicinal Chemistry, Drug Target, Active Bace1 Inhibitor +11

Enantioselective Synthesis of the Oxadecalin Core of Phomactin A via a Highly Stereoselective Diels−Alder Reaction

Sherry R. Chemler, Ulrich Iserloh, Samuel J. Danishefsky · Organic Letters · 2001 · 79 citations

Potent pyrrolidine- and piperidine-based BACE-1 inhibitors

Ulrich Iserloh, Yusheng Wu, Jared N. Cumming et al. · Bioorganic & Medicinal Chemistry Letters · 2007 · 78 citations · Full text

Medicinal Chemistry, Medicine, Piperidine-based Bace-1 Inhibitors +6

Discovery of an orally efficaceous 4-phenoxypyrrolidine-based BACE-1 inhibitor

Ulrich Iserloh, Jianping Pan, Andrew W. Stamford et al. · Bioorganic & Medicinal Chemistry Letters · 2007 · 69 citations · Full text

Medicinal Chemistry, Medicine, Pharmacological Agent +4