Concepedia

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Lymphocyte activation in HIV-1 infection. II. Functional defects of CD28− T cells

DOI

209

Citations

0

References

1994

Year

Nicola Borthwick, Margarita Bofill, Wendy M. Gombert, Arne N. Akbar, Eva Medina, Kimitaka Sagawa, Marc Lipman, Margaret Johnson, George Janossy
AIDS

Abstract

In HIV-1 infection activated CD3+CD28- T cells accumulate but are unresponsive to mitogens and anti-CD28. These cells appear to represent terminally differentiated effector cells which fail to respond to further stimuli because of the absence of a CD28 second signal.