Hyperpolarized 13C Magnetic Resonance Reveals Early- and Late-Onset Changes to <i>in vivo</i> Pyruvate Metabolism in the Failing Heart

Abstract

Despite early changes associated with cardiac energetics and (13)C incorporation into the Krebs cycle, pyruvate oxidation was maintained until DCM developed, when the heart's capacity to oxidize both pyruvate and fats was reduced. Hyperpolarized (13)C MR may be important to characterize metabolic changes that occur during heart failure progression.