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Immunology, Cell Culture, Cell Proliferation +18

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Mouse Monoclonal Antibody, Antagonistic Activity, Immunocytochemical Technique +11

A Ubiquitous Chromatin Opening Element (UCOE) Confers Resistance to DNA Methylation–mediated Silencing of Lentiviral Vectors

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Gene amplification and vector engineering to achieve rapid and high-level therapeutic protein production using the Dhfr-based CHO cell selection system

Jonathan J. Cacciatore, Lawrence A. Chasin, Edward F. Leonard · Biotechnology Advances · 2010 · 99 citations

Gene Amplification, Engineering, Medicine +12

The use of UCOE vectors in combination with a preadapted serum free, suspension cell line allows for rapid production of large quantities of protein

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