Concepedia

Spinal 5-HT7 Receptors Play an Important Role in the Antinociceptive and Antihyperalgesic Effects of Tramadol and Its Metabolite, O-Desmethyltramadol, via  Activation of Descending Serotonergic Pathways

Ömer Yanarateş, Ahmet Doğrul, Altan Şahin, Ali Sızlan, Melik Seyrek, Özgür Akgül, Orhan Kozak, Ercan Kurt, Ülkü Aypar

Anesthesiology · 2010 · 90 citations · 43 references

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Abstract

These findings suggest that the descending serotonergic pathways and spinal 5-HT7 receptors play a crucial role in the antinociceptive and antihyperalgesic effects of tramadol and M1.

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