Spinal 5-HT7 Receptors Play an Important Role in the Antinociceptive and Antihyperalgesic Effects of Tramadol and Its Metabolite, O-Desmethyltramadol, via Activation of Descending Serotonergic Pathways - Concepedia

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Spinal 5-HT7 Receptors Play an Important Role in the Antinociceptive and Antihyperalgesic Effects of Tramadol and Its Metabolite, O-Desmethyltramadol, via Activation of Descending Serotonergic Pathways

DOI Full Paper Access

90

Citations

43

References

2010

Year

Ömer Yanarateş, Ahmet Doğrul, Altan Şahin, Ali Sızlan, Melik Seyrek, Özgür Akgül, Orhan Kozak, Ercan Kurt, Ülkü Aypar

Abstract

These findings suggest that the descending serotonergic pathways and spinal 5-HT7 receptors play a crucial role in the antinociceptive and antihyperalgesic effects of tramadol and M1.

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