Concepedia

Single-step detection of mutant huntingtin in animal and human tissues: A bioassay for Huntington’s disease

Andreas Weiss, Dorothée Abramowski, Miriam Bibel, Ruth A. Bodner, Vanita Chopra, Marian DiFiglia, Jonathan H. Fox, Kimberly B. Kegel, Corinna Klein, Stephan Grueninger,

Analytical Biochemistry · 2009 · 129 citations · 37 references

DOI

Concepts

References

37

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes

Marcy E. MacDonald · Cell · 1993 · 8.4K citations · Full text

, , +13

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

Ji-Hu Zhang, Thomas D.Y. Chung, Kevin R. Oldenburg · SLAS DISCOVERY · 1999 · 7K citations · Full text

, , +16

Exon 1 of the HD Gene with an Expanded CAG Repeat Is Sufficient to Cause a Progressive Neurological Phenotype in Transgenic Mice

Laura Mangiarini, Kirupa Sathasivam, Mary J. Seller et al. · Cell · 1996 · 3.1K citations · Full text

, , +17

A polymorphic DNA marker genetically linked to Huntington's disease

James F. Gusella, Nancy S. Wexler, P. Michael Conneally et al. · Nature · 1983 · 2.3K citations

, , +12

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

Montserrat Arrasate, Siddhartha Mitra, Erik S. Schweitzer et al. · Nature · 2004 · 2K citations

, , +15