Embedded multicellular spheroids as a biomimetic 3D cancer model for evaluating drug and drug-device combinations

Tensional homeostasis and the malignant phenotype

Matthew J. Paszek, Nastaran Zahir, Kandice R. Johnson et al. · Cancer Cell · 2005 · 3.9K citations

Malignant Disease, Physiology, Homeostatic Mechanism +6

E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells.

U. Frixen, Jürgen Behrens, Matthew S. Sachs et al. · The Journal of Cell Biology · 1991 · 1.6K citations

Selective Loss, Medicine, Cell Adhesion +12

Migration of tumor cells in 3D matrices is governed by matrix stiffness along with cell-matrix adhesion and proteolysis

Muhammad H. Zaman, Linda M. Trapani, Alisha L. Sieminski et al. · Proceedings of the National Academy of Sciences · 2006 · 1.2K citations · Full text

Tissue Engineering, Engineering, Cell Adhesion +22

Method for generation of homogeneous multicellular tumor spheroids applicable to a wide variety of cell types

Jens M. Kelm, Nicholas Timmins, Catherine J. Brown et al. · Biotechnology and Bioengineering · 2003 · 906 citations

Engineering tumors with 3D scaffolds

Claudia Fischbach, Ruth Chen, Takuya Matsumoto et al. · Nature Methods · 2007 · 814 citations

Tissue Engineering, Scaffolds, Engineering +7