Concepedia

Endothelial-Specific Deletion of Connexin40 Promotes Atherosclerosis by Increasing CD73-Dependent Leukocyte Adhesion

Christos Chadjichristos, K.E. Ludwig Scheckenbach, Toon A.B. van Veen, M.Z. Richani Sarieddine, Cor de Wit, Zhihong Yang, Isabelle Roth, Matthew Bacchetta, Hema Viswambharan, Bernard Foglia,

Circulation · 2009 · 132 citations · 44 references

DOI

Abstract

Cx40-mediated gap junctional communication contributes to a quiescent nonactivated endothelium by propagating adenosine-evoked antiinflammatory signals between endothelial cells. Alteration in this mechanism by targeting Cx40 promotes leukocyte adhesion to the endothelium, thus accelerating atherosclerosis.

References

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A direct colorimetric assay for Ca2+-stimulated ATPase activity

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