Molecular characterization of bifunctional hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase from Plasmodium falciparum

Mutations in dihydropteroate synthase are responsible for sulfone and sulfonamide resistance in <i>Plasmodium falciparum</i>

Tony Triglia, John G. Menting, Craig M. Wilson et al. · Proceedings of the National Academy of Sciences · 1997 · 421 citations · Full text

Life Sciences, Molecular Biology, Pharmacology +14

Sequence Variation of the Hydroxymethyldihydropterin Pyrophosphokinase: Dihydropteroate Synthase Gene in Lines of the Human Malaria Parasite, <i>Plasmodium falciparum</i>, with Differing Resistance to Sulfadoxine

Darren R. Brooks, Ping Wang, Martin Read et al. · European Journal of Biochemistry · 1994 · 372 citations · Full text

Life Sciences, Genetics, Molecular Biology +13

Primary structure and expression of the dihydropteroate synthetase gene of Plasmodium falciparum.

Tony Triglia, Alan F. Cowman · Proceedings of the National Academy of Sciences · 1994 · 301 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +12

Sulfadoxine resistance in the human malaria parasite <i>Plasmodium falciparum </i>is determined by mutations in dihydropteroate synthetase and an additional factor associated with folate utilization

Ping Wang, Martin Read, Paul F. G. Sims et al. · Molecular Microbiology · 1997 · 299 citations · Full text

Life Sciences, Genetics, Pharmacology +15

Crystal structure of the anti-bacterial sulfonamide drug target dihydropteroate synthase

Aniruddha Achari, J.N. Champness, P.K. Bryant et al. · Nature Structural Biology · 1997 · 293 citations

Life Sciences, Chemistry, Medicinal Chemistry +9