Concepedia

SNPs in the TGF-β Signaling Pathway Are Associated with Increased Risk of Brain Metastasis in Patients with Non–Small-Cell Lung Cancer

Qianxia Li, Huanlei Wu, Bei Chen, G. Hu, Liu Huang, Kai Qin, Yu Chen, Xianglin Yuan, Zhongxing Liao

PLoS ONE · 2012 · 35 citations · 19 references

DOIFull text

Open access

Abstract

We found the GG genotype of SMAD6: rs12913975 and TT genotype of INHBC: rs4760259 to be associated with risk of brain metastasis in patients with NSCLC. This finding, if confirmed, can help to identify patients at high risk of brain metastasis.

References

19

Prophylactic Cranial Irradiation in Extensive Small-Cell Lung Cancer

Ben J. Slotman, Corinne Faivre‐Finn, G. Kramer et al. · New England Journal of Medicine · 2007 · 1.1K citations · Full text

Validation of the RTOG recursive partitioning analysis (RPA) classification for brain metastases

Laurie E. Gaspar, Charles Scott, Kevin Murray et al. · International Journal of Radiation Oncology*Biology*Physics · 2000 · 530 citations

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Phase III Comparison of Prophylactic Cranial Irradiation Versus Observation in Patients With Locally Advanced Non–Small-Cell Lung Cancer: Primary Analysis of Radiation Therapy Oncology Group Study RTOG 0214

Elizabeth Gore, Kyounghwa Bae, Stuart J. Wong et al. · Journal of Clinical Oncology · 2010 · 311 citations · Full text

The impact of smoking status, disease stage, and index tumor site on second primary tumor incidence and tumor recurrence in the head and neck retinoid chemoprevention trial.

Fadlo R. Khuri, Edward S. Kim, J. Jack Lee et al. · PubMed · 2001 · 245 citations

, , +17

Factors Affecting the Risk of Brain Metastases After Definitive Chemoradiation for Locally Advanced Non–Small-Cell Lung Carcinoma

Theodore J. Robnett, Mitchell Machtay, James Stevenson et al. · Journal of Clinical Oncology · 2001 · 173 citations